Cancer incidence in the AGRICAN cohort study (2005-2011)
Type de document
journalArticle
Langue source
Anglais
Titre français
Titre anglais
Cancer incidence in the AGRICAN cohort study (2005-2011)
Auteur(s)
- LEMARCHAND Clémentine
- TUAL Séverine
- LEVÊQUE-MORLAIS Noémie
- PERRIER Stéphanie
- BELOT Aurélien
- VELTEN Michel
- GUIZARD Anne-Valérie
- MARCOTULLIO Elisabeth
- MONNEREAU Alain
- CLIN Bénédicte
- BALDI Isabelle
- LEBAILLY Pierre
Editeur(s)
Autre(s)
Id
XA6BDTUH
Version
1694
Date ajout
6 janvier 2021 16:24
Date modification
6 janvier 2021 16:24
Résumé anglais
Background
Numerous studies have been conducted among farmers but very few of them were large prospective cohorts and included a significant proportion of women and farmworkers. Our aim was to compare cancer incidence in the cohort (overall, by sex, by work on farm, occupational status and pesticide use) with the general population.
Methods
More than 180,000 participants in the AGRICAN cohort were matched to cancer registries to identify cancer cases diagnosed from enrolment (2005-2007) to 31st December 2011. We calculated standardized incidence ratios (SIRs) and 95% confidence interval (CI).
Results
Over the period, 11,067 incident cancer cases were identified (7,304 men and 3,763 women). Overall cancer incidence in the cohort and the general population was not different. Moreover, SIRs were significantly higher for prostate cancer (SIR= 1.07, 95%CI 1.03-1.11) and non-Hodgkin lymphoma (SIR= 1.09, 95%CI 1.01-1.18) among men, skin melanoma among women (SIR= 1.23, 95%CI 1.05-1.43) and multiple myeloma (men: SIR= 1.38, 95%CI 1.18-1.62; women: SIR= 1.26, 95%CI 1.02-1.54). In contrast SIRs were lower for upper aero-digestive tract and respiratory cancers. Increase in risk was greater in male farmworkers for prostate and lip cancer, in female farmworkers for skin melanoma and in male farmowners for multiple myeloma. Moreover, incidence of multiple myeloma and skin melanoma was higher among male and female pesticide users respectively.
Conclusion
We found a decreased incidence for tobacco-related cancers and an increased incidence of prostate cancers, skin melanoma and multiple myeloma. Specific sub-groups had a higher cancer incidence related to occupational status and pesticide use.
Note
None
CRAW tags
- AB - Non-spécifique
- cohort studies
- FREDO santé humaine
- farmers
- GEO France
- incidence
- neoplasms
- pesticide
- polémique
WEB tags
Titre de la publication
Cancer epidemiology
Volume
49
Pages
175-185
Date caractères
2017-8
Date publication
24 août 2017
Doi
10.1016/j.canep.2017.06.003
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Issn
1877-7821
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