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Prostate cancer risk among French farmers in the AGRICAN cohort

Type de document
journalArticle
Langue source
Anglais
Titre français
Titre anglais
Prostate cancer risk among French farmers in the AGRICAN cohort
Auteur(s)
  • LEMARCHAND Clémentine
  • TUAL Séverine
  • BOULANGER Mathilde
  • LEVÊQUE-MORLAIS Noémie
  • PERRIER Stéphanie
  • CLIN Bénédicte
  • GUIZARD Anne-Valérie
  • VELTEN Michel
  • RIGAUD Emma
  • BALDI Isabelle
  • LEBAILLY Pierre
Editeur(s)
Autre(s)
Id
S4FGBN86
Version
2085
Url zotero
https://www.zotero.org/groups/2567444/items/S4FGBN86
Date ajout
6 janvier 2021 16:24
Date modification
19 janvier 2021 10:59
Résumé anglais
OBJECTIVES: Prostate cancer is one of the most frequent cancers among men worldwide. Its etiology is largely unknown, but an increased risk has been repeatedly observed among farmers. Our aim was to identify occupational risk factors for prostate cancer among farmers in the prospective cohort study AGRICAN. METHODS: Data on lifetime agricultural exposures (type of crops, livestock and tasks including pesticide use, re-entry and harvesting) were collected from the enrolment questionnaire. During the period from enrolment (2005-2007) to 31 December 2009, 1672 incident prostate cancers were identified. Hazard ratios (HR) were estimated using Cox regression analysis. RESULTS: We found an increased risk for cattle breeders using insecticides [HR 1.20, 95% confidence interval (95% CI) 1.01-1.42] with a significant dose-response relationship with number of cattle treated (P for trend 0.01). A dose-response relationship was also observed with the number of hogs (P for trend 0.06). We found an excess of prostate cancer risk among people involved in grassland activities, mainly in haymaking (HR 1.18, 95% CI 1.02-1.36). Pesticide use and harvesting among fruit growers were associated with an elevated prostate cancer risk, with a two-fold increased risk for the largest area. For potato and tobacco producers, an elevated prostate cancer risk was observed for almost all tasks, suggesting a link with pesticide exposure since all of them potentially involved pesticide exposure. CONCLUSIONS: Our analysis suggests that the risk of prostate cancer is increased in several farming activities (cattle and hog breeding, grassland and fruit-growing) and for some tasks including pesticide use.
Note
None
CRAW tags
  • AB - Non-spécifique
  • FREDO santé humaine
  • GEO France
  • pesticide
  • polémique
WEB tags
  • aged
  • agricultural workers' diseases
  • agrochemicals
  • animals
  • cohort studies
  • farmers
  • humans
  • male
  • middle aged
  • occupational exposure
  • pesticides
  • prospective studies
  • prostatic neoplasms
  • risk factors
Titre de la publication
Scandinavian Journal of Work, Environment & Health
Volume
42
Pages
144-152
Date caractères
Mar 2016
Date publication
24 mars 2016
Doi
10.5271/sjweh.3552 Le DOI est une URL unique de référencement d'une publication. Il est donc plus fiable et permanent qu'une URL classique
Issn
1795-990X L’ISSN est un code de 8 chiffres servant à identifier les journaux, revues, magazines, périodiques de toute nature et sur tous supports, papier comme électronique.